Dimethyl Isosorbide

At a glance

CAS number

5306-85-4

INCI name

Dimethyl Isosorbide

Function

solvent, penetration enhancer, carrier

Typical use level

5%–25%

Solubility

both

Stable pH

4–8

CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.

Also known as

DMI Isosorbide Dimethyl Ether 2,5-Dimethoxy-1,4:3,6-dianhydrosorbitol Arlasolve DMI

Compatibility

Works well with:
Retinol Vitamin C Niacinamide Hyaluronic Acid Glycerin Salicylic Acid

Dimethyl Isosorbide is broadly compatible with both hydrophilic and lipophilic actives, making it versatile as a co-solvent and carrier. It can solubilize ingredients that are otherwise difficult to incorporate, such as retinol and salicylic acid, improving their delivery into the skin. No commonly reported incompatibilities, though formulators should evaluate interactions with specific actives at final pH.

Formulation notes

Dimethyl Isosorbide is a bio-based, biodegradable cyclic ether solvent derived from sorbitol that acts as a penetration enhancer by transiently disrupting the lipid bilayer of the stratum corneum to facilitate delivery of actives. It is miscible with both water and common organic solvents, providing exceptional flexibility in formulation. It is considered low-irritation and non-sensitizing at typical use levels, though concentrations above 25% may cause mild transient sensations on sensitive skin.

Frequently asked questions

Related ingredients

• Caprylic/Capric TriglycerideEmollient
• CyclopentasiloxaneEmollient
• Isopropyl MyristateEmollient
• Dipropylene GlycolSolvent
• Benzyl AlcoholPreservative
• Butylene GlycolHumectant