Tranexamic Acid

At a glance

CAS number

1197-18-8

INCI name

Tranexamic Acid

Function

skin brightener, hyperpigmentation corrector, anti-inflammatory, active

Typical use level

2%–5%

Solubility

water

Stable pH

4–7

CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.

Also known as

TXA trans-4-(aminomethyl)cyclohexanecarboxylic acid trans-AMCHA Cyklokapron 4-(aminomethyl)cyclohexane-1-carboxylic acid

Compatibility

Works well with:
Niacinamide Kojic Acid Alpha Arbutin Vitamin C (Ascorbic Acid) Hyaluronic Acid Glycerin

Tranexamic Acid is generally well-tolerated alongside other brightening actives such as niacinamide and alpha arbutin, making it suitable for multi-active depigmentation formulas. It is water-soluble and should be incorporated into the aqueous phase. No widely documented incompatibilities with common cosmetic ingredients exist, though combining multiple low-pH actives may require pH balancing to maintain stability and skin comfort.

Formulation notes

Tranexamic Acid is a synthetic lysine derivative that inhibits plasminogen activator activity, thereby reducing UV-induced prostaglandin production and melanin synthesis; it is used topically to address hyperpigmentation, melasma, and uneven skin tone. Formulators favor it for its good tolerability profile relative to more irritating brighteners, its stability across a broad cosmetic pH range, and its compatibility with a wide array of co-actives. It is considered safe for cosmetic use at typical concentrations of 2–5%, though it was originally developed as a pharmaceutical antifibrinolytic agent.

Frequently asked questions

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