At a glance
- CAS number
- 25513-46-6
- INCI name
- Polyglutamic Acid
- Function
- humectant, film former, skin conditioning
- Typical use level
- 0.5%–5%
- Solubility
- water
- Stable pH
- 4–7
CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.
Also known as
PGA gamma-PGA poly-gamma-glutamic acid natto gum fermented glutamic acid polymer
Compatibility
Works well with:
Hyaluronic Acid Niacinamide Glycerin Panthenol Ceramides Sodium PCA
Polyglutamic Acid is broadly compatible with most water-phase actives and humectants, and is often layered with hyaluronic acid for complementary moisture-retention effects. It performs best in slightly acidic to neutral formulas; highly alkaline conditions can hydrolyze the peptide backbone. No widely documented incompatibilities, though high electrolyte concentrations may reduce its hygroscopic performance.
Formulation notes
Polyglutamic Acid is a naturally derived biopolymer produced via bacterial fermentation of Bacillus subtilis, best known from natto. It functions as a potent humectant — reported to hold significantly more moisture than hyaluronic acid — while also forming a lightweight occlusive film on the skin surface that reduces transepidermal water loss. It is well tolerated at typical use levels, though formulators should confirm molecular weight grade, as high-MW and low-MW forms differ in skin penetration depth and sensory profile.
Frequently asked questions
What is Polyglutamic Acid?
Polyglutamic Acid is a humectant, film former, skin conditioning used in cosmetic and personal-care formulation. Typical use level is 0.5%–5%. It is water-soluble. Stable in the pH 4–7 range.
What is Polyglutamic Acid used for?
Polyglutamic Acid is used as humectant, film former, skin conditioning in cosmetic and personal-care formulations.
What is the typical use level of Polyglutamic Acid?
Polyglutamic Acid is typically used at 0.5%–5% in the finished formulation. Always confirm against your supplier's technical data sheet.
What is the CAS number of Polyglutamic Acid?
The CAS registry number for Polyglutamic Acid is 25513-46-6. Its INCI name is Polyglutamic Acid.
At what pH is Polyglutamic Acid stable?
Polyglutamic Acid is generally stable in the pH 4–7 range.
What ingredients are compatible with Polyglutamic Acid?
Polyglutamic Acid works well with Hyaluronic Acid, Niacinamide, Glycerin, Panthenol, Ceramides, Sodium PCA.
Related ingredients
- DextranHumectant
- Sodium HyaluronateHumectant
- Hydrogenated PolyisobuteneEmollient
- BetaineHumectant
- Butylene GlycolHumectant
- ErythritolHumectant