Squalane

At a glance

CAS number

111-01-3

INCI name

Squalane

Function

emollient, solvent, active

Typical use level

1%–100%

Solubility

oil

CAS number and synonyms are sourced from PubChem. Function, usage levels, pH and compatibility are AI-assisted formulation guidance — verify against your supplier's technical data sheet and applicable regulations before use.

Also known as

2,6,10,15,19,23-Hexamethyltetracosane Perhydrosqualene Cosbiol Robane Dodecahydrosqualene Hexamethyltetracosane Spinacane Vitabiosol Tetracosane, 2,6,10,15,19,23-hexamethyl- Hexamethyl tetracosane Pripure 3759 footcream

Compatibility

Works well with:
Niacinamide Retinol Vitamin C Hyaluronic Acid Ceramides Peptides AHA/BHA Benzoyl Peroxide Jojoba Oil Argan Oil

Squalane is exceptionally chemically inert and broadly compatible with nearly all cosmetic ingredients across oil and water phases. It is non-comedogenic, oxidatively stable, and does not saponify, making it safe alongside actives and preservatives. No significant incompatibilities are widely documented under typical cosmetic formulation conditions.

Formulation notes

Plant-derived (typically from sugarcane or olive) squalane is a fully saturated hydrocarbon; unlike squalene (CAS 111-02-4), it is highly resistant to oxidation. No regulatory use restrictions apply in cosmetics. Suitable for all skin types including sensitive and acne-prone skin. Can be used as a standalone facial oil (100%) or incorporated into emulsions, serums, and lip products.

Frequently asked questions

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