Yes, and for many skin types this is actually the more complete approach than using either product alone. The layering logic comes from understanding what each product does: colloidal oatmeal provides anti-inflammatory soothing and a light occlusive film via beta-glucan, while a ceramide cream provides the structural lipids (ceramides, fatty acids, cholesterol) that actually rebuild the intercellular matrix of the stratum corneum. They address different parts of the same problem, and they do not compete with each other.
The standard layering order is thinnest to thickest: if you are using a ceramide serum, that goes on first after cleansing, while skin is still slightly damp (which helps humectants absorb). Then a colloidal oatmeal lotion as a mid-weight moisturizing layer. Then, if needed in the evening, a richer ceramide cream on top. In the morning, the oatmeal lotion alone may be enough, with SPF over it.
An important note on timing: do not rush layering. Give each layer 30 to 60 seconds to settle before applying the next. This is less about absorption and more about not physically pilling the products against each other, which wastes product and can reduce efficacy.
For oily or acne-prone skin with a damaged barrier, this approach — ceramide serum plus a lightweight colloidal oatmeal lotion — avoids the heaviness of a rich cream while still covering all three functional jobs (lipid replenishment, humectancy, and occlusivity). For dry or very dry skin, adding a rich ceramide cream as the final layer in the evening provides the heavier occlusion needed overnight.
What does not layer well: heavy petrolatum-based products applied before lighter serums or ceramide creams. Petrolatum in particular, applied as a first layer, creates an occlusive seal that significantly reduces penetration of everything applied afterward. If you are using a petrolatum-heavy product, it belongs as the last step — the "icing" on top, not the base.
Read the full guide on best moisturizers for a damaged skin barrier by skin type →